25th Symposium

Signal Transduction
at the
Blood-Brain Barriers

18 June 2023
Uppsala University Main Building, Hall IX



A 1st (250$), 2nd (200$) and 3rd (150$) Young Investigators best oral presentation award will be granted (* eligible speakers). Kindly sponsored by the IBBS and the Brain Barriers Signaling.



09:00 – 09:25


09:25 – 09:30

Opening Words


Wnt Signaling and Development

Session chair: Stefan Liebner

09:30 – 10:00

Plenary Speaker
Kevin Boyé (Paris Cardiovascular Research Center, France)
Netrin1 binding to Unc5B regulates blood-CNS barriers integrity via the Wnt signaling

10:00 – 10:20

* Muyu Situ
Uncovering the role of connexins and Yap in blood brain barrier hyperpermeability and microvascular injury in cerebral amyloid angiopathy

10:20 – 10:40

* Gergo Porkolab
cARLA: a small molecule cocktail for robust induction of blood-brain barrier properties

10:40 – 11:00

Ines Martinez-Corral
Tanycytic VEGF receptor signaling in the bloodhypothalamus barrier: a new player in the communication between the brain and the periphery

11:00 - 11:20

* Juliette Vaurs
TRIM47 is a crucial regulator of brain endothelial cell functions

11:20 – 11:40

Coffee / tea break


Pathogens and Inflammation at the Blood-Brain Barriers

Session chair: Pierre-Olivier Couraud

11:40 – 12:10

Plenary Speaker
Sandrine Bourdoulous (University of Paris, France)
A role for ANGPTL4 in vascular protection of the brain during sepsis

12:10 – 12:30

* Nadine Vollmuth
Estrogen signaling contributes to Group B Streptococcal disruption and invasion of brain endothelial cells

12:30 – 12:50

* Tushar Deshpande
Vascular basement membrane laminins contribute to the functional integrity of the blood vessels

12:50 – 13:10

Michal Toborek
An interplay between HIV infection and cerebrovascular toxicity of methamphetamine

13:00 – 14:00



Blood-Brain Barriers in Health and Disease

Session chair: Malgorzata Burek

14:00 – 14:30

Plenary Speaker
Stefan Momma (Goethe University Frankfurt, Germany)
Extracellular vesicle-mediated transfer of functional molecules from the periphery to the brain

14:30 – 14:50

Masanori Tachikawa
Placenta-derived extracellular vesicles: their unique characteristics of the blood-brain barrier transport

14:50 – 15:10

* Julia K. Sundheimer
Multi-omics characterization of the blood-brain barrier in molecular groups of ependymoma

15:10 – 15:30

Irena Loryan
Unraveling the role of biological barriers in the development of chemotherapy-induced peripheral neuropathy

15:30 – 16:00

Coffee / tea break


Blood-Brain Barriers in Health and Disease continued

Session chair: Reiner Haseloff

16:00 – 16:20

* Matt Govendir
A sticky situation: the influence of microvessel mechanics on cerebral malaria pathogenesis 2. Brain barriers in disease

16:20 – 16:40

* Irene Spera
Open pathways for cerebrospinal fluid outflow at the cribriform plate


Announcement of best presentation awards.
Concluding Remarks and End of Satellite Symposium (CVB 2023 starts at 17:00 in the same building)

You can download the program here
You can find the session abstracts here