Wednesday, September 11, 2024 Downloadable PROGRAM BOOKLET
14:00 Registration
Hanging posters in the poster room
16:00 Introductory remarks
16:15 Plenary Lecture - Alon Friedman
Blood-brain barrier modulation: from mechanistic insights to clinical applications
17:00– 18:00 SESSION I. Infectious disease and the BBB
Session chairs: Malgorzata Burek, Michal Toborek
17:00 Brandon J. Kim Meningeal pathogens disrupt blood-brain barrier properties
17:20 Monique Stins Differential brain vascular inflammation in cerebral malaria pathogenesis
17:40 Ildikó Dunay Immune response and pathogen invasion at the choroid plexus in the
onset of cerebral toxoplasmosis
18:00-19:00 Poster session I
19:00 Welcome Reception
Thursday, September 12, 2024
09:00 – 10:20 SESSION II. Models of the brain barriers and transport mechanisms
Session chairs: Imola Wilhelm, Yuri Persidsky
09:00 Antje Appelt-Menzel In vitro strategies to improve cellular maturity of hiPSC-derived blood-brain barrier endothelium
09:20 Fruzsina R. Walter Development of a novel human cell-based blood-brain barrier and midbrain organoid lab-on-a-chip model
09:40 Claus U. Pietrzik An artificial receptor for transport purposes across the blood brain barrier
10:00 Ellaine Salvador Variously-sized molecules permeate the blood-brain barrier after Tumor Treating Fields (TTFields) administration in vitro
10:20 Coffee break
10:50 – 12:40 SESSION III. Brain barriers in aging and age-related disorders
Session chairs:Egle Solito, Claus Pietrzik
10:50 Katalin Todorov-Völgyi Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging
11:20 Attila E. Farkas Brain vasculature rejuvenation by combined senolytic and progenitor cell therapy
11:40 Eszter Farkas Neurovascular dysfunction and neuronal hyperexcitability in the APP/PS1 transgenic mouse model of Alzheimer’s disease
12:00 Petr Pleskač Deciphering the role of the choroid plexus and the brain barriers in the pathogenesis of Alzheimer’s disease
12:20 Selvi Ince Differentially dysregulated ANGPT-2/TIE-2 signalling axis in Alzheimer’s disease and vascular dementia
12:40 Lunch
14:00 Poster session II
15:30 Coffee Break
16:00 – 17:10 SESSION IV. Pathology of brain barriers 1
Session chairs: Eszter Farkas, Matthew Campbell
16:00 Ádám Dénes Microglia modulate neurovascular responses via compartment-specific
purinergic mechanism
16:30 Hideaki Nishihara Examining the effects of blood-brain barrier dysfunction on clinical manifestations in multiple sclerosis
16:50 BUSINESS MEETING
17:30 Poster session III.
19:00 Wine tasting and dinner
Friday, September 13, 2024
09:00 -11:00 SESSION V. Signaling and tight junctions
Session chairs: Szilvia Veszelka, Xavier Decleves
09:00 Anuska V. Andjelkovic Connexin-43 and Hippo/Yap signaling in brain endothelial barrier dysfunction in cerebral amyloid angiopathy
09:20 Csilla Fazakas MiR-146a-5p and TGF-β collectively regulate brain endothelial Paqr5 and angiogenesis in response to tumour-derived extracellular vesicles
09:40 Patric Turowski Molecular regulation of paracellular and transcellular leakage at the blood-brain barrier
10:00 Malgorzata Burek Interaction network of the tight junction protein occludin
10:20 Matthew Campbell Regulation of claudin-5 at the blood brain barrier
10:40 Gergő Porkoláb A mechano-metabolic couplingcontrols blood-brain barrier integrity
11:00 Coffee break
11:30-13:10 SESSION VI. Pathology of brain barriers 2
Session chairs:Anuska Andjelkovic, Patric Turowski
11:30 Michal Toborek Circadian control of the blood-brain barrier and cerebrovascular toxicity of environmental toxicants
11:50 Yuri Persidsky Blood brain barrier injury by electronic cigarettes and alcohol: mechanism and protective strategy
12:10 Szilvia Veszelka Protection of brain endothelial cells as a therapeutic target in brain diseases
12:30 György Bagdy The role of BBB integrity in human stress and inflammation-associated depression
12:50 Megan Ritson The effect of repeated low-level inflammation on the cerebrovasculature
13:10 Poster prizes and close of the conference
13:30 Lunch
15:00-17:00 Historical Tour of Szeged (optional, with advanced booking only)
Saturday, September 14, 2024
Optional social programs (not incl. registration fee):Illuminated hot air balloons at the World Championship (airport of Szeged)
https://www.airportszeged.hu/szia2024
Excursion to Opusztaszer National Historical Park